F.D.A. Commissioner Marty Makary Resigns After Weeks of Pressure

FDA Commissioner Marty Makary has resigned after weeks of intense scrutiny and internal pressure, multiple outlets reported. The resignation follows reports that President Trump had approved a plan to oust Makary — a report the White House publicly downplayed — and contemporaneous reporting that Makary was preparing to step down. Makary was confirmed as FDA commissioner in March 2025. The New York Times said the agency’s top food official will serve as acting commissioner. Observers describe Makary’s tenure as tumultuous, marked by leadership upheaval, mass layoffs, political pressure and public disputes with drugmakers. Agency officials are scrambling to steady regulatory priorities, reassure stakeholders and manage an exit that leaves unfinished reviews and awkward staff memos.