Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors / Science Translational Medecine

Torahito A. Gao, Ryan M. Shih, Justin D. Clubb, Shao-Hsi Hung, Tanya Singh, Laura B. James-Allan, Ga / science - Science Translational Medicine, Volume 18, Issue 839, March 2026.

43 hrs / oncodaily

Biomimetic platform developed to enhance CAR T cell therapy against leukemia

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Glen Clack: Are Cell Therapies Too Expensive and Too Toxic to Scale?

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Engineered CAR-T cells block key protein to break solid tumors' immune shield

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Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors

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Monday, March 9, 2026, 4:22 am / permalink 20364 / 6 stories in 2 days

Elizabeth McKenna: New Cancer Grand Challenges Teams Announced / OncoDaily

oncodaily - Elizabeth McKenna, Executive Editor of Cancer Discovery, shared a post on X: “The new Cancer Grand Challenges teams have just been announced! Read about the teams tackling cancer avoidance, mechanisms […]

#healthcare #biotech #drugdevelopment #oncology #healthcarefinance #cancerresearch #researchfunding

Accelerating Cancer Immunotherapy: Parker Institute & ASCO Launch Young Investigator Award

7 hrs / oncodaily

Douglas R. Lowy, MD, FAACR, and John T. Schiller, PhD, FAACR, Honored with the 2026 Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research

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Shared patterns of dysregulated gene expression across squamous cell carcinomas unveil predictors for prognosis and drug sensitivity

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Hidden metabolism found operating inside the cell nucleus

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Immune Pathways Help Identify Patients with Cancer and HIV Most Likely to Experience Reservoir Decay with Anti-PD1 Therapy

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Study finds no evidence that prostate cancer drugs interact with anticoagulants to increase bleeding, clotting risks

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UK cancer death rates down to their lowest level on record

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OncoGrants Weekly: Top 10 OncoGrants to Apply for in 2026: Deadlines from March to June

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A multicenter retrospective study of plasma d‑dimer levels for evaluating treatment response in multiple myeloma

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Prescription‑dose stratification improves deep learning‑based VMAT dose prediction in locally advanced NSCLC

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Gian Paolo Andreoletti: What If Cancer Originated Primarily From Systemic Metabolism?

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Stephen Williams: Proud to Serve as Global PI for SunRISe-2 Trial

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Binay Shah: 2nd Annual Binaytara Oklahoma Thoracic Oncology Conference

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Sheraz Azhar: OncsCare Shortlisted for Medilink Midlands Business Awards 2026

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Anton Safonov: Germline-Somatic Interactions Predict Treatment Resistance in Breast Cancer

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Patrick Hwu: Why Some Cancer Cells Evade the Immune System During Early Spread

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Vivek Subbiah: Commentary on Australia’s MoST Program

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David C. Michael: How Epigenetics Shapes Cancer Beyond DNA Mutations

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Samuel Stevens: Australian Oncologist Perspectives on Time Toxicity

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International Women’s Day Highlights 2026: Honoring Women in Oncology

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Ruben Mesa: Clinical and Translational Research Award Winners at Myeloid Malignancy Workshop

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Joanna Metzner-Sadurski Highlights Key Takeaways from ASCO CoP Health Policy Webinar

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ESTRO Issues New Guidance on IMRT and IGRT for Rectal Cancer – Radiotherapy and Oncology

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Jeff Hanna Appointed Co-opted Board Member at UK Oncology Nursing Society

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Jia Jenny Liu Shares Takeaways from APOS 2026 on the Future of Precision Oncology

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Arturo LoAIza-Bonilla: AI in Lung Cancer Care at New York Lung Cancer Foundation Summit

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Jemma Longley Returns to Teach Immunotherapy at The Institute of Cancer Research

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Rahul Gosain Reviews Treatment Strategies for Triple Negative Breast Cancer

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Ola Khorshid Leads Discussion on Global Health and Lung Cancer Disparities

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Felipe Couñago: Global Assessment of Radiotherapy Access Gap and Future Needs

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Daniel Stover: Multidisciplinary Breast Cancer Symposium at UChicago

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International Women’s Day 2026: Championing women in cancer research

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Targeting erythroid progenitor cell metabolism to enhance cancer immunotherapy

3 days / nature

Performance of breast cancer risk prediction algorithms across mammography systems in the UK screening programme

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Alicia Zhou: How Open Data Could Accelerate Immunotherapy Discoveries

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Lorenzo de la Rica: Cancer Grand Challenges Announces Five New Global Teams with £100M Investment

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ASCO GU 2026 Highlights: Belzutifan + Lenvatinib and Pembrolizumab in RCC – IUCS / OncoDaily

oncodaily - International Urology Cancer Summit shared a post on LinkedIn: “IUCS Journal Club – Highlights from ASCO GU 2026: Targeting HIF-2α in RCC. This Journal Club session reviews the data from […]

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10 Ongoing Clinical Trials on Immunotherapy in Renal Cancer

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ASCO GU 2026 Highlights: Belzutifan + Lenvatinib and Pembrolizumab in RCC – IUCS

4 days / oncodaily

Belzutifan+pembrolizumab post-surgery helps kidney cancer patients at high risk for relapse stay cancer-free longer

9 days / medicalxpress

Saturday, March 7, 2026, 9:22 am / permalink 20321 / 3 stories in 3 days

New AI tool predicts best pancreatic cancer treatment / Medical Express

medicalxpress - A new tool co-developed by investigators from Cedars-Sinai Health Sciences University can predict which of two available chemotherapy options for pancreatic cancer would be more effective for an individual patient.

#healthcare #biotech #digitalhealth #medicaldevices #oncology #pancreaticcancer

Why This Rural Health System Is Scaling AI for Point-of-Care Decision Making

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New AI tool predicts best pancreatic cancer treatment

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Cedars-Sinai AI tool predicts best chemotherapy for pancreatic cancer patients

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Saturday, March 7, 2026, 12:23 am / permalink 20310 / 3 stories in 4 days

Servier Boosts Presence in Rare Cancers With $2.5B Acquisition of Day One Biopharma / MedCity

Frank Vinluan / medcitynews - Day One Biopharmaceuticals is Servier’s biggest acquisition yet, topping the $2.4 billion it paid to buy Shire’s cancer business in 2018. Day One markets Ojemda, approved for treating pediatric low-grade glioma, the most common type of brain cancer in chi…

#healthcare #pharmaceuticals #biotech #mergersandacquisitions #drugdevelopment #oncology #healthcarefinance

Agreement with Day One Biopharmaceuticals to Expand Glioma Portfolio – Servier

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Servier: A Caregiver’s Powerful Story on Rare Disease

4 days / oncodaily

Servier Boosts Presence in Rare Cancers With $2.5B Acquisition of Day One Biopharma

4 days / medcitynews / Frank Vinluan

Servier to buy Day One for $2.5B, gaining rare oncology medicines

4 days / endpoints / Kyle LaHucik

Saturday, March 7, 2026, 12:22 am / permalink 20306 / 4 stories in 4 days

Adding Hormone Therapy to PORT Might Not Benefit Patients with Recurrent Prostate Cancer and PSA of 0.5 ng/mL or Less / ESMO

esmo - Findings from the POSEIDON meta-analysis of the MARCAP consortium

#healthcare #pharmaceuticals #publichealth #oncology

Adding Hormone Therapy to PORT Might Not Benefit Patients with Recurrent Prostate Cancer and PSA of 0.5 ng/mL or Less

6 days / esmo

Majid Al Othman: POSEIDON Meta-Analysis Results in Post-Prostatectomy Salvage RT

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Sault skiiers bring home medals from youth championships

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Thursday, March 5, 2026, 3:23 am / permalink 20175 / 3 stories in 6 days

Antitumour Activity of Rezatapopt Provides Proof of Concept for p53 Reactivation in Patients with TP53 Y220C-mutated Solid Tumours / ESMO

esmo - Findings from the PYNNACLE study

#healthcare #pharmaceuticals #biotech #drugdevelopment #oncology

Rezatapopt Shows Early Activity in TP53 Y220C–Mutated Solid Tumors

7 days / oncodaily

Targeting the untargetable cancer—rezatapopt, an oral p53 reactivator

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Antitumour Activity of Rezatapopt Provides Proof of Concept for p53 Reactivation in Patients with TP53 Y220C-mutated Solid Tumours

9 days / esmo

Jayastu Senapati: Trial of Rezatapopt in TP53-Y220C Mutated MDS/AML

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Rashid Lui: First-in-Class Oral Selective p53 Reactivator Looks Promising

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Xin Lu on Targeting Mutant p53 in Solid Tumors with Rezatapopt – NEJM Group

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Florent Peyraud: Restoring Function to a Variant of p53 in Solid Tumors

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Aydah AlAwadhi: Targeting the “Undruggable” p53 – A Long Awaited Proof of Principle

12 days / oncodaily

Monday, March 2, 2026, 2:22 am / permalink 19973 / 8 stories in 9 days

Merck Splits Oncology Business Unit as Keytruda Patent Expiry Nears / OncoDaily

oncodaily - On February 23, 2026, Merck announced a reorganization of its Human Health structure into two business units: an Oncology Business Unit and a Specialty, Pharma & Infectious Diseases Business Unit. […]

#healthcare #pharmaceuticals #biotech #drugdevelopment #oncology #healthcarefinance

Merck KGaA drops two cancer trials on assets from SpringWorks deal

6 days / endpoints / Reynald Castaneda

No OS Improvement with CDK4/6 Inhibitors Used in First- Compared with Second-Line Treatment in Patients with HR-positive, HER2-negative ABC

8 days / esmo

Cancer Research UK partners with the Royal College of Surgeons of England to help people with rectal cancer avoid unnecessary surgery

8 days / cancerresearchuk / Krishna Sharma

A domain-adaptive deep contrastive network for magnetic resonance imaging-driven bladder cancer classification

8 days / nature

Multicenter ex vivo evaluation of an α-mannosidase–targeted fluorescent probe for intraoperative margin assessment in breast cancer

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Neoadjuvant pembrolizumab plus chemotherapy in older patients with early-stage triple-negative breast cancer: real-world insights from neo-real/GBECAM-0123

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Merck looks to expand Welireg label following combo readouts with Keytruda, Lenvima

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Merck Splits Oncology Business Unit as Keytruda Patent Expiry Nears

12 days / oncodaily

Merck reorganizes; Blackstone to fund trials for J&J drug

16 days / endpoints / ENDPOINTS

Saturday, February 28, 2026, 3:22 am / permalink 19937 / 9 stories in 11 days

Microplastics discovered in prostate tumors / Medical Express

medicalxpress - Small fragments of plastic were found in 9 out of 10 patients with prostate cancer, and in higher levels inside tumors than in nearby noncancerous tissue, a new study finds. The small, single-center study was led by researchers at NYU Langone Health, its …

#healthcare #publichealth #oncology

How worried should you be about microplastics?

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María Natalia Gandur Quiroga: Structural Shifts in How We Think About Prostate Cancer

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Microplastics found in 90% of prostate cancer tumors, study reveals

14 days / sciencedaily

Microplastics discovered in prostate tumors

15 days / medicalxpress

Saturday, February 28, 2026, 12:23 am / permalink 19928 / 4 stories in 11 days

Boehringer wins accelerated approval for first-line use of lung cancer drug / Endpoints

Lei Lei Wu / endpoints - The FDA greenlit an expanded label for Boehringer Ingelheim’s lung cancer drug Hernexeos, marking the first use of the Commissioner's National Priority Voucher for a new indication. Boehringer won an accelerated

#healthcare #pharmaceuticals #publichealth #governmentpolicy #biotech #drugdevelopment #fda #oncology

What to know about lung cancer

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Lurbinectedin in Oncology: Mechanism, Clinical Data, Evolving Role, and Future Directions

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Patrick Soon-Shiong: Anktiva Plus Keytruda Shows Potential to Prolong Survival in Patients with Lung Cancer

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Aakash Desai HER2-Mutant NSCLC: Navigating the TKI vs ADC Debate

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Stephen V Liu: Intracranial Efficacy of Trastuzumab Deruxtecan in HER2-Mutant NSCLC

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FDA Approves Zongertinib for HER2-Mutated NSCLC – Oncology Brothers

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Zongertinib Receives FDA Accelerated Approval in HER2-Mutant NSCLC

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FDA Voucher Leads to Speedy Approval of Boehringer Drug for First-Line Use in Lung Cancer

12 days / medcitynews / Frank Vinluan

Boehringer wins accelerated approval for first-line use of lung cancer drug

12 days / endpoints / Lei Lei Wu

Saturday, February 28, 2026, 12:23 am / permalink 19927 / 9 stories in 11 days

Novartis to build $23B radioligand therapy site / Beckers

Ella Jeffries / beckershospitalreview - Novartis will construct a 46,000-square-foot radioligand therapy manufacturing site in Denton, Texas, as part of its $23 billion U.S. investment. The facility will be Novartis’ fifth radioligand therapy site in the U.S. and its first in Texas, according t…

#healthcare #pharmaceuticals #biotech #drugdevelopment #oncology #healthcarefinance

Oklahoma pharmacy school to expand radiopharmaceutical access with new facility

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Novartis to build $23B radioligand therapy site

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Novartis to build another radioligand factory; Germany steps up probe into Gerresheimer

13 days / endpoints / Anna Brown

Saturday, February 28, 2026, 12:23 am / permalink 19926 / 3 stories in 11 days

Patient dies in MacroGenics' cancer study, FDA puts trial on hold / Endpoints

Max Gelman / endpoints - The FDA has placed a partial clinical hold on MacroGenics’ Phase 2 study in gynecologic cancers after one patient died and three others experienced life-threatening side effects, the company disclosed Tuesday. The patient who died ...

#healthcare #pharmaceuticals #publichealth #biotech #drugdevelopment #fda #oncology

Kyowa Kirin ends OX40 trials after Amgen balked, safety concern

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FDA partially pauses cancer drug trial after patient death

13 days / beckershospitalreview / Paige Twenter

Patient dies in MacroGenics' cancer study, FDA puts trial on hold

14 days / endpoints / Max Gelman

Saturday, February 28, 2026, 12:23 am / permalink 19925 / 3 stories in 11 days

Cancer blood test fails to catch disease earlier in major study / Medical Express

medicalxpress - A blood test designed to find cancer early did not work as hoped in a major new study, according to the company that makes it.

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Experts Discuss Early Detection Strategies in New Podcast Episode – International Cardio-Oncology Society

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Ruiling Yuan on National and Local Efforts to Improve Early Detection

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Why did my doctor push Grail’s dubious cancer test?

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Sucharu Prakash: What Do the GRAIL Trials Results Mean?

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Cancer blood test fails to catch disease earlier in major study

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Thursday, February 26, 2026, 7:24 pm / permalink 19851 / 7 stories in 12 days

More Research, Less Cancer: £250m raised to transform the future of cancer research / Cancer Research UK

Charlotte Mathé / cancerresearchuk - We’ve reached an incredible moment - £250m raised for our More Research, Less Cancer campaign. This milestone brings us more than halfway to our £400m goal and accelerates our mission to prevent, detect and treat cancer earlier and more effectively. The p…

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Top OncoGrants of the Week: Pilot Funding, Team Science, Clinical Trials, and Survivorship Awards (2026)

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COLONTOWN Expands Patient Support With New Online Space for Colorectal Cancer Care

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Laser heat therapy plus immunotherapy may dramatically improve survival for those with deadly brain cancer

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Final Phase 3 CONVERT Trial Results: Neoadjuvant CAPOX vs Capecitabine-Based ChemoRT in Locally Advanced Rectal Cancer

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Screening Programme by Primary Colonoscopy or Two Rounds of Two-Stool FIT Detects More Lower-Stage CRCs than Usual Care

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Joanna Sadowska: Pfizer Gets FDA Approval for BRAFTOVI as First-Line Treatment for Metastatic Colorectal Cancer

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Good vibrations: could sound waves help diagnose prostate cancer?

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Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia

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Cervical cancer rates plummet among states with high HPV vaccination rates

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Woman's regret over botched Brazilian butt lift

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Tuesday, February 24, 2026, 1:24 pm / permalink 19675 / 53 stories in 14 days

Gilead to acquire cell therapy manufacturer for $7.8B / Beckers

Paige Twenter / beckershospitalreview - In a deal worth $7.8 billion, Gilead Sciences has entered a definitive agreement to acquire Arcellx, a biotech company developing a cell therapy for multiple myeloma. Gilead announced the acquisition agreement a few months after Arcellx published positive…

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Vir–Astellas Prostate Cancer Deal and ALX Oncology’s 2025 Results Set 2026 Catalysts

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Gilead–Arcellx Deal: Up to $7.8B for Anito-cel CAR-T in Multiple Myeloma

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'Off the shelf' immunotherapy could get a lift from gene-edited natural killer cells

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Megan Melody on CAR T-Cell Therapy Advances in Autoimmune Disease

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Gilead to acquire cell therapy manufacturer for $7.8B

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Gilead Sciences Is Acquiring Arcellx and Partnered Multiple Myeloma Drug in $7.8B Deal

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Gilead to acquire cell therapy partner Arcellx for $7.8B

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Monday, February 23, 2026, 4:23 pm / permalink 19605 / 7 stories in 15 days

Perioperative Enfortumab Vedotin Plus Pembrolizumab Improves EFS, OS and pCR in Patients with MIBC Who Are Ineligible for Cisplatin / ESMO

esmo - Findings from the KEYNOTE-905/EV-303 study

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Blood test predicts which bladder cancer patients may safely skip surgery

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Perioperative enfortumab vedotin + pembrolizumab tied to improved outcomes with bladder cancer

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Padcev-Keytruda combo delivers more positive data in bladder cancer

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Ahmet Dirican: MIBC Staging Is No Longer Just Anatomical

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Shilpa Gupta: Grateful to ASCO For the Opportunity to Serve as ASCOGU26 Featured Voice

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Perioperative Enfortumab Vedotin Plus Pembrolizumab Improves EFS, OS and pCR in Patients with MIBC Who Are Ineligible for Cisplatin

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Jad Chahoud Celebrates Nabil Adra Advancing Pembrolizumab-EV in Bladder Cancer

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Monday, February 23, 2026, 2:22 am / permalink 19558 / 15 stories in 16 days

Data and Decisions in Advanced NSCLC at the 2026 TTLC Symposia – IASLC / OncoDaily

oncodaily - International Association for the Study of Lung Cancer (IASLC) shared a post on LinkedIn: “2026 TTLC Symposia Event Data and Decisions in Advanced NSCLC The treatment landscape for advanced NSCLC is evolving […]

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Christine M. Lovly։ Dr. Ross Camidge’s Incredible Presentation at the IASLC TTLC Meeting

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Mysterious Virus Hiding Inside Common Gut Bacterium Linked to Colorectal Cancer / Discover

discovermagazine - A previously unknown virus may be the key to assessing the risk of colorectal cancer and improving diagnosis.

#healthcare #publichealth #biotech #oncology

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Grail’s Galleri Blood Test Falls Short in Large Cancer-Screening Study, Shares Sink 50% / MedCity

Frank Vinluan / medcitynews - Despite missing statistical significance, Grail said the observation of trending improvement suggests potential for better results with more time, so the company is extending follow up by up to a year. More detailed trial results will be submitted for pre…

#healthcare #publichealth #biotech #medicaldevices #oncology

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Your Cat May Share the Same Cancer Genes as You, and Offer Clues for Treatment / Discover

discovermagazine - Learn how cats and humans can share key cancer mutations — and why those similarities could guide future treatment research.

#healthcare #pharmaceuticals #publichealth #biotech #drugdevelopment #oncology

Cats may hold clues for human cancer treatment

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Tag Directory / ONCOLOGY showing 1–20 of 22

Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors / Science Translational Medecine

Elizabeth McKenna: New Cancer Grand Challenges Teams Announced / OncoDaily

ASCO GU 2026 Highlights: Belzutifan + Lenvatinib and Pembrolizumab in RCC – IUCS / OncoDaily

New AI tool predicts best pancreatic cancer treatment / Medical Express

Servier Boosts Presence in Rare Cancers With $2.5B Acquisition of Day One Biopharma / MedCity

Adding Hormone Therapy to PORT Might Not Benefit Patients with Recurrent Prostate Cancer and PSA of 0.5 ng/mL or Less / ESMO

Antitumour Activity of Rezatapopt Provides Proof of Concept for p53 Reactivation in Patients with TP53 Y220C-mutated Solid Tumours / ESMO

Merck Splits Oncology Business Unit as Keytruda Patent Expiry Nears / OncoDaily

Microplastics discovered in prostate tumors / Medical Express

Boehringer wins accelerated approval for first-line use of lung cancer drug / Endpoints

Novartis to build $23B radioligand therapy site / Beckers

Patient dies in MacroGenics' cancer study, FDA puts trial on hold / Endpoints

Cancer blood test fails to catch disease earlier in major study / Medical Express

More Research, Less Cancer: £250m raised to transform the future of cancer research / Cancer Research UK

Gilead to acquire cell therapy manufacturer for $7.8B / Beckers

Perioperative Enfortumab Vedotin Plus Pembrolizumab Improves EFS, OS and pCR in Patients with MIBC Who Are Ineligible for Cisplatin / ESMO

Data and Decisions in Advanced NSCLC at the 2026 TTLC Symposia – IASLC / OncoDaily

Mysterious Virus Hiding Inside Common Gut Bacterium Linked to Colorectal Cancer / Discover

Grail’s Galleri Blood Test Falls Short in Large Cancer-Screening Study, Shares Sink 50% / MedCity

Your Cat May Share the Same Cancer Genes as You, and Offer Clues for Treatment / Discover

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