Gene clues reveal why some rare leukemia patients resist tagraxofusp therapy
medicalxpress - Researchers at The University of Texas MD Anderson Cancer Center have identified why some patients with a rare type of leukemia, called blastic plasmacytoid dendritic cell neoplasm (BPDCN), eventually develop resistance to tagraxofusp, the first Food and …
AI Summary: Researchers have identified decreased TXNRD1 and related molecular changes that appear linked to resistance against tagraxofusp in BPDCN patients. This insight exposes a plausible resistance mechanism and opens opportunities to test predictive biomarkers or combination strategies to overcome failure, which is welcome news for clinicians facing a stubborn, high‑risk disease.
Medieval babies and adults buried together in Sweden were not related, archaeologists discover — raising big questions about early Christian burial practices
livescience - In an unexpected discovery, researchers found that three medieval Swedish cemeteries held children buried with unrelated adults.
AI Summary: Archaeological and genetic analyses reveal medieval Swedish burial patterns that placed infants and children alongside unrelated adults, including female infants buried among men. The findings challenge assumptions about kinship‑based internment and suggest shifting funerary practices during early Christianization, prompting fresh questions about social identity and ritual in the period.